7otu: Difference between revisions
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==Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2== | ==Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2== | ||
<StructureSection load='7otu' size='340' side='right'caption='[[7otu]]' scene=''> | <StructureSection load='7otu' size='340' side='right'caption='[[7otu]], [[Resolution|resolution]] 0.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTU FirstGlance]. <br> | <table><tr><td colspan='2'>[[7otu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7otu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7otu OCA], [https://pdbe.org/7otu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7otu RCSB], [https://www.ebi.ac.uk/pdbsum/7otu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7otu ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7otu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7otu OCA], [https://pdbe.org/7otu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7otu RCSB], [https://www.ebi.ac.uk/pdbsum/7otu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7otu ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rabe von | [[Category: Pappenheim, F Rabe von]] | ||
[[Category: Rindfleisch S]] | [[Category: Rindfleisch, S]] | ||
[[Category: Tittmann K]] | [[Category: Tittmann, K]] | ||
[[Category: Bmp]] | |||
[[Category: Lyase]] | |||
[[Category: Ompd]] | |||
[[Category: Orotidine 5'-monophosphate decarboxylase]] | |||
[[Category: Ump]] | |||
