1h30: Difference between revisions
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'''C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6''' | '''C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6''' | ||
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[[Category: Tisi, D.]] | [[Category: Tisi, D.]] | ||
[[Category: Ullrich, A.]] | [[Category: Ullrich, A.]] | ||
[[Category: | [[Category: Axl/sky/mer ligand]] | ||
[[Category: | [[Category: Calcium-binding]] | ||
[[Category: | [[Category: Egf-like domain]] | ||
[[Category: | [[Category: Laminin g-like domain]] | ||
[[Category: | [[Category: Vitamin k-dependent protein]] | ||
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Revision as of 15:21, 2 May 2008
C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6
Overview
Receptor tyrosine kinases of the Axl family are activated by Gas6, the product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated in cell survival, adhesion, and migration. The receptor-binding site of Gas6 is located within a C-terminal pair of laminin G-like (LG) domains that do not resemble any other receptor tyrosine kinase ligand. We report the crystal structure at 2.2-A resolution of a Gas6 fragment spanning both LG domains (Gas6-LG). The structure reveals a V-shaped arrangement of LG domains strengthened by an interdomain calcium-binding site. LG2 of Gas6-LG contains two unusual features: an alpha-helix cradled by one edge of the LG beta-sandwich and a conspicuous patch of surface-exposed hydrophobic residues. Mutagenesis of some residues in this patch reduces Gas6-LG binding to the extracellular domain of Axl as well as Axl activation in glioblastoma cells, identifying a component of the receptor-binding site of Gas6.
About this Structure
1H30 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:12218057 Page seeded by OCA on Fri May 2 18:21:51 2008
