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==Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 2-fluorogeranylgeranyl diphosphate==
==Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 2-fluorogeranylgeranyl diphosphate==
<StructureSection load='3p5r' size='340' side='right' caption='[[3p5r]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3p5r' size='340' side='right'caption='[[3p5r]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3p5r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pacific_yew Pacific yew]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P5R FirstGlance]. <br>
<table><tr><td colspan='2'>[[3p5r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pacific_yew Pacific yew]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FGG:(2Z,6E,10E)-2-FLUORO-3,7,11,15-TETRAMETHYLHEXADECA-2,6,10,14-TETRAEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>FGG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FGG:(2Z,6E,10E)-2-FLUORO-3,7,11,15-TETRAMETHYLHEXADECA-2,6,10,14-TETRAEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>FGG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p5p|3p5p]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p5p|3p5p]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TDC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46220 Pacific yew])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TDC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46220 Pacific yew])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Taxadiene_synthase Taxadiene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.17 4.2.3.17] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Taxadiene_synthase Taxadiene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.17 4.2.3.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5r OCA], [http://pdbe.org/3p5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p5r RCSB], [http://www.ebi.ac.uk/pdbsum/3p5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5r OCA], [https://pdbe.org/3p5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5r RCSB], [https://www.ebi.ac.uk/pdbsum/3p5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TASY_TAXBR TASY_TAXBR]] Catalyzes the cyclization of the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to taxa-4,11-diene, the parent olefin with a taxane skeleton.  
[[https://www.uniprot.org/uniprot/TASY_TAXBR TASY_TAXBR]] Catalyzes the cyclization of the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to taxa-4,11-diene, the parent olefin with a taxane skeleton.  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Pacific yew]]
[[Category: Pacific yew]]
[[Category: Taxadiene synthase]]
[[Category: Taxadiene synthase]]
Retrieved from "https://proteopedia.org/3p5r"