3pf7: Difference between revisions

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==Crystal structure of BoxB with malonate bound to the diiron center==
==Crystal structure of BoxB with malonate bound to the diiron center==
<StructureSection load='3pf7' size='340' side='right' caption='[[3pf7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3pf7' size='340' side='right'caption='[[3pf7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3pf7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Azoev Azoev]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PF7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3pf7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Azoev Azoev]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PF7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3per|3per]], [[3pm5|3pm5]], [[3q1g|3q1g]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3per|3per]], [[3pm5|3pm5]], [[3q1g|3q1g]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">boxB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59406 AZOEV])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">boxB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59406 AZOEV])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Benzoyl-CoA_2,3-dioxygenase Benzoyl-CoA 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.12.21 1.14.12.21] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Benzoyl-CoA_2,3-dioxygenase Benzoyl-CoA 2,3-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.12.21 1.14.12.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pf7 OCA], [http://pdbe.org/3pf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pf7 RCSB], [http://www.ebi.ac.uk/pdbsum/3pf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pf7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pf7 OCA], [https://pdbe.org/3pf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pf7 RCSB], [https://www.ebi.ac.uk/pdbsum/3pf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pf7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BOXB_AZOEV BOXB_AZOEV]] The BoxA/BoxB complex catalyzes the aerobic reduction/oxygenation of the aromatic ring of benzoyl-CoA to form 2,3-dihydro-2,3-dihydroxybenzoyl-CoA. BoxB acts as the benzoyl-CoA oxygenase, after being reduced by the reductase component BoxA. BoxAB does not act on NADH or benzoate.<ref>PMID:15458418</ref>   
[[https://www.uniprot.org/uniprot/BOXB_AZOEV BOXB_AZOEV]] The BoxA/BoxB complex catalyzes the aerobic reduction/oxygenation of the aromatic ring of benzoyl-CoA to form 2,3-dihydro-2,3-dihydroxybenzoyl-CoA. BoxB acts as the benzoyl-CoA oxygenase, after being reduced by the reductase component BoxA. BoxAB does not act on NADH or benzoate.<ref>PMID:15458418</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Azoev]]
[[Category: Azoev]]
[[Category: Benzoyl-CoA 2,3-dioxygenase]]
[[Category: Benzoyl-CoA 2,3-dioxygenase]]
[[Category: Large Structures]]
[[Category: Ermler, U]]
[[Category: Ermler, U]]
[[Category: Fuchs, G]]
[[Category: Fuchs, G]]
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