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==Crystal structure of H159A APAH complexed with acetylspermine==
==Crystal structure of H159A APAH complexed with acetylspermine==
<StructureSection load='3q9e' size='340' side='right' caption='[[3q9e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3q9e' size='340' side='right'caption='[[3q9e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q9e]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_49678 Atcc 49678]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q9E FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q9e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_49678 Atcc 49678]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q9E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SP5:N-[3-({4-[(3-AMINOPROPYL)AMINO]BUTYL}AMINO)PROPYL]ACETAMIDE'>SP5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SP5:N-[3-({4-[(3-AMINOPROPYL)AMINO]BUTYL}AMINO)PROPYL]ACETAMIDE'>SP5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q9b|3q9b]], [[3q9c|3q9c]], [[3q9f|3q9f]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q9b|3q9b]], [[3q9c|3q9c]], [[3q9f|3q9f]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aphA, aph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40837 ATCC 49678])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aphA, aph ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40837 ATCC 49678])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9e OCA], [http://pdbe.org/3q9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q9e RCSB], [http://www.ebi.ac.uk/pdbsum/3q9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9e OCA], [https://pdbe.org/3q9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q9e RCSB], [https://www.ebi.ac.uk/pdbsum/3q9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/APHA_MYCRA APHA_MYCRA]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides.  
[[https://www.uniprot.org/uniprot/APHA_MYCRA APHA_MYCRA]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides.  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Atcc 49678]]
[[Category: Atcc 49678]]
[[Category: Large Structures]]
[[Category: Christianson, D W]]
[[Category: Christianson, D W]]
[[Category: Lombardi, P M]]
[[Category: Lombardi, P M]]
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