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==Crystal Structure of Streptococcus Pyogenes Uridine Phosphorylase Reveals a Subclass of the NP-I Superfamily==
==Crystal Structure of Streptococcus Pyogenes Uridine Phosphorylase Reveals a Subclass of the NP-I Superfamily==
<StructureSection load='3qpb' size='340' side='right' caption='[[3qpb]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='3qpb' size='340' side='right'caption='[[3qpb]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qpb]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m6 Streptococcus pyogenes serotype m6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QPB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qpb]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m6 Streptococcus pyogenes serotype m6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QPB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">M6_Spy1599 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301450 Streptococcus pyogenes serotype M6])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">M6_Spy1599 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301450 Streptococcus pyogenes serotype M6])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qpb OCA], [http://pdbe.org/3qpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qpb RCSB], [http://www.ebi.ac.uk/pdbsum/3qpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qpb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qpb OCA], [https://pdbe.org/3qpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qpb RCSB], [https://www.ebi.ac.uk/pdbsum/3qpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qpb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q5XA29_STRP6 Q5XA29_STRP6]] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.[RuleBase:RU361131]  
[[https://www.uniprot.org/uniprot/Q5XA29_STRP6 Q5XA29_STRP6]] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.[RuleBase:RU361131]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Uridine phosphorylase|Uridine phosphorylase]]
*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pyogenes serotype m6]]
[[Category: Streptococcus pyogenes serotype m6]]
[[Category: Uridine phosphorylase]]
[[Category: Uridine phosphorylase]]
Retrieved from "https://proteopedia.org/3qpb"