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==Crystal structure of epoxide hydrolase for polyether lasalocid A biosynthesis==
==Crystal structure of epoxide hydrolase for polyether lasalocid A biosynthesis==
<StructureSection load='3rga' size='340' side='right' caption='[[3rga]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='3rga' size='340' side='right'caption='[[3rga]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rga]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'streptomyces_lasaliensis' 'streptomyces lasaliensis']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'streptomyces_lasaliensis' 'streptomyces lasaliensis']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ILD:(4R,5S)-3-[(2R)-2-{(2S,2R,4S,5S,5R)-2,5-DIETHYL-5-[(1S)-1-HYDROXYETHYL]-4-METHYLOCTAHYDRO-2,2-BIFURAN-5-YL}BUTANOYL]-4-METHYL-5-PHENYL-1,3-OXAZOLIDIN-2-ONE'>ILD</scene>, <scene name='pdbligand=LSB:(4R,5S)-3-[(2R,3S,4S)-2-ETHYL-5-[(3R)-2-ETHYL-3-[2-[(2R,3R)-2-ETHYL-3-METHYL-OXIRAN-2-YL]ETHYL]OXIRAN-2-YL]-3-HYDROXY-4-METHYL-PENTANOYL]-4-METHYL-5-PHENYL-1,3-OXAZOLIDIN-2-ONE'>LSB</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ILD:(4R,5S)-3-[(2R)-2-{(2S,2R,4S,5S,5R)-2,5-DIETHYL-5-[(1S)-1-HYDROXYETHYL]-4-METHYLOCTAHYDRO-2,2-BIFURAN-5-YL}BUTANOYL]-4-METHYL-5-PHENYL-1,3-OXAZOLIDIN-2-ONE'>ILD</scene>, <scene name='pdbligand=LSB:(4R,5S)-3-[(2R,3S,4S)-2-ETHYL-5-[(3R)-2-ETHYL-3-[2-[(2R,3R)-2-ETHYL-3-METHYL-OXIRAN-2-YL]ETHYL]OXIRAN-2-YL]-3-HYDROXY-4-METHYL-PENTANOYL]-4-METHYL-5-PHENYL-1,3-OXAZOLIDIN-2-ONE'>LSB</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lasB, lsd19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=324833 'Streptomyces lasaliensis'])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lasB, lsd19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=324833 'Streptomyces lasaliensis'])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rga OCA], [http://pdbe.org/3rga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rga RCSB], [http://www.ebi.ac.uk/pdbsum/3rga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rga ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rga OCA], [https://pdbe.org/3rga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rga RCSB], [https://www.ebi.ac.uk/pdbsum/3rga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rga ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LSD19_STRLS LSD19_STRLS]] Epoxide hydrolase responsible for the double epoxide-opening cyclization of bisepoxyprelasalocid A to form lasalocid A, a polyether antibiotic. In vitro, accepts various substrate analogs differing in the left segment of lasalocid and epoxide stereochemistry to afford products with excellent regioselectivity.<ref>PMID:18710235</ref> <ref>PMID:19025863</ref> <ref>PMID:20394359</ref> <ref>PMID:21375229</ref>   
[[https://www.uniprot.org/uniprot/LSD19_STRLS LSD19_STRLS]] Epoxide hydrolase responsible for the double epoxide-opening cyclization of bisepoxyprelasalocid A to form lasalocid A, a polyether antibiotic. In vitro, accepts various substrate analogs differing in the left segment of lasalocid and epoxide stereochemistry to afford products with excellent regioselectivity.<ref>PMID:18710235</ref> <ref>PMID:19025863</ref> <ref>PMID:20394359</ref> <ref>PMID:21375229</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Epoxide hydrolase|Epoxide hydrolase]]
*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Streptomyces lasaliensis]]
[[Category: Streptomyces lasaliensis]]
[[Category: Large Structures]]
[[Category: Chen, X]]
[[Category: Chen, X]]
[[Category: Hotta, K]]
[[Category: Hotta, K]]
Retrieved from "https://proteopedia.org/3rga"