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==Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii STANDL==
==Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii STANDL==
<StructureSection load='3sh3' size='340' side='right' caption='[[3sh3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3sh3' size='340' side='right'caption='[[3sh3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sh3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_wilsonii Dioclea wilsonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SH3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_wilsonii Dioclea wilsonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SH3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3B:D-VINYLGLYCINE'>A3B</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3B:D-VINYLGLYCINE'>A3B</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rrd|3rrd]], [[3rs6|3rs6]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rrd|3rrd]], [[3rs6|3rs6]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh3 OCA], [http://pdbe.org/3sh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sh3 RCSB], [http://www.ebi.ac.uk/pdbsum/3sh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sh3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh3 OCA], [https://pdbe.org/3sh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sh3 RCSB], [https://www.ebi.ac.uk/pdbsum/3sh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sh3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LECA_DIOWI LECA_DIOWI]] D-mannose/D-glucose-binding lectin with hemagglutinating activity towards rabbit and human erythrocytes. In rats, elicits an acute inflammatory response by inducing neutrophil migration and induces dose-dependent paw edema.<ref>PMID:21694673</ref> <ref>PMID:21924319</ref>   
[[https://www.uniprot.org/uniprot/LECA_DIOWI LECA_DIOWI]] D-mannose/D-glucose-binding lectin with hemagglutinating activity towards rabbit and human erythrocytes. In rats, elicits an acute inflammatory response by inducing neutrophil migration and induces dose-dependent paw edema.<ref>PMID:21694673</ref> <ref>PMID:21924319</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Dioclea wilsonii]]
[[Category: Dioclea wilsonii]]
[[Category: Large Structures]]
[[Category: Assreuy, A M.S]]
[[Category: Assreuy, A M.S]]
[[Category: Bezerra, G A]]
[[Category: Bezerra, G A]]
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