3sku: Difference between revisions

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==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==
==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==
<StructureSection load='3sku' size='340' side='right' caption='[[3sku]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
<StructureSection load='3sku' size='340' side='right'caption='[[3sku]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SKU FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-1 Hhv-1] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [http://pdbe.org/3sku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [http://www.ebi.ac.uk/pdbsum/3sku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [https://pdbe.org/3sku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [https://www.ebi.ac.uk/pdbsum/3sku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>   
[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Glycoproteins B and D|Glycoproteins B and D]]
*[[Glycoproteins B and D|Glycoproteins B and D]]
*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Hhv-1]]
[[Category: Hhv-1]]
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Bhargava, A K]]
[[Category: Bhargava, A K]]
[[Category: Carfi, A]]
[[Category: Carfi, A]]
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