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==Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.==
==Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.==
<StructureSection load='3syx' size='340' side='right' caption='[[3syx]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='3syx' size='340' side='right'caption='[[3syx]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3syx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SYX FirstGlance]. <br>
<table><tr><td colspan='2'>[[3syx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SYX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPRED1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPRED1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3syx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syx OCA], [http://pdbe.org/3syx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3syx RCSB], [http://www.ebi.ac.uk/pdbsum/3syx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3syx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3syx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syx OCA], [https://pdbe.org/3syx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3syx RCSB], [https://www.ebi.ac.uk/pdbsum/3syx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3syx ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN]] Legius syndrome. The disease is caused by mutations affecting the gene represented in this entry.  
[[https://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN]] Legius syndrome. The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN]] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).  
[[https://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN]] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).  
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Acton, T B]]
[[Category: Acton, T B]]
[[Category: Ciccosanti, C]]
[[Category: Ciccosanti, C]]

Revision as of 08:16, 29 June 2022

Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.

3syx, resolution 2.45Å

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