3t0o: Difference between revisions

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==Crystal Structure Analysis of Human RNase T2==
==Crystal Structure Analysis of Human RNase T2==
<StructureSection load='3t0o' size='340' side='right' caption='[[3t0o]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='3t0o' size='340' side='right'caption='[[3t0o]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3t0o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T0O FirstGlance]. <br>
<table><tr><td colspan='2'>[[3t0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T0O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNASET2, RNASE6PL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNASET2, RNASE6PL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_T(2) Ribonuclease T(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.1 3.1.27.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonuclease_T(2) Ribonuclease T(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.1 3.1.27.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t0o OCA], [http://pdbe.org/3t0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t0o RCSB], [http://www.ebi.ac.uk/pdbsum/3t0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t0o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t0o OCA], [https://pdbe.org/3t0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t0o RCSB], [https://www.ebi.ac.uk/pdbsum/3t0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t0o ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/RNT2_HUMAN RNT2_HUMAN]] Cystic leukoencephalopathy without megalencephaly. The disease is caused by mutations affecting the gene represented in this entry.  
[[https://www.uniprot.org/uniprot/RNT2_HUMAN RNT2_HUMAN]] Cystic leukoencephalopathy without megalencephaly. The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RNT2_HUMAN RNT2_HUMAN]] Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.<ref>PMID:16620762</ref> <ref>PMID:19525954</ref> <ref>PMID:22735700</ref>   
[[https://www.uniprot.org/uniprot/RNT2_HUMAN RNT2_HUMAN]] Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.<ref>PMID:16620762</ref> <ref>PMID:19525954</ref> <ref>PMID:22735700</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Ribonuclease|Ribonuclease]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
*[[Temp|Temp]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Kraetzner, R]]
[[Category: Kraetzner, R]]
[[Category: Sheldrick, G]]
[[Category: Sheldrick, G]]
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