3t5o: Difference between revisions

<StructureSection load='3t5o' size='340' side='right' caption='[[3t5o]], [[Resolution|resolution]] 2.87&Aring;' scene=''>

<table><tr><td colspan='2'>[[3t5o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T5O FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5o OCA], [http://pdbe.org/3t5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t5o RCSB], [http://www.ebi.ac.uk/pdbsum/3t5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5o ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN]] Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:[http://omim.org/entry/612446 612446]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.  

[[http://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.