Pannexin: Difference between revisions

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== Function ==

'''Pannexin''' (PNX) is a family of single membrane channel-forming glycoprotein. The family is comprised of 3 members. PNX1 is expressed in mammalian tissue and plays a role in releasing signals for apoptotic cell clearance. In addition, PNX1 plays a role in propagation of calcium waves, regulation of vascular tone, mucociliary lung clearance, taste-bud function<ref>PMID:22305965</ref>. PNX1 mediates release of ATP which acts as a signal recruiting macrophages to apoptotic cells. PNX1 activation requires cleavage of its C-terminal tail by caspase<ref>PMID:22311983</ref>.

== Relevance ==

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== Structural highlights ==

The 3D structure of human <scene name='91/916893/Cv/3'>PNX1 shows the pore to constitute 7 subunits</scene>. The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1. The pore transmembrane domains are occupied by lipid molecules which interact with hydrophobic sidechains<ref>PMID:35133866</ref>.

The 3D structure of human <scene name='91/916893/Cv/3'>PNX1 shows the pore to constitute 7 subunits</scene>. The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1. The pore transmembrane domains are occupied by <scene name='91/916893/Cv/4'>lipid molecules</scene> which interact with hydrophobic sidechains<ref>PMID:35133866</ref>.

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@@ Line 3: / Line 3: @@
 == Function ==
-'''Pannexin''' (PNX) is a family of single membrane channel-forming glycoprotein.  The family is comprised of 3 members.  PNX1 is expressed in mammalian tissue and plays a role in releasing signals for apoptotic cell clearance.  In addition, PNX1 plays a role in propagation of calcium waves, regulation of vascular tone, mucociliary lung clearance, taste-bud function<ref>PMID:22305965</ref>.  PNX1 mediates release of ATP which acts as a signal recruiting macrophages to apoptotic cells.  PNX1 activation requires cleavage of its C-terminal tail by caspase<ref>PMID:22311983</ref>.
+'''Pannexin''' (PNX) is a family of single membrane channel-forming glycoprotein.  The family is comprised of 3 members.  PNX1 is expressed in mammalian tissue and plays a role in releasing signals for apoptotic cell clearance. In addition, PNX1 plays a role in propagation of calcium waves, regulation of vascular tone, mucociliary lung clearance, taste-bud function<ref>PMID:22305965</ref>.  PNX1 mediates release of ATP which acts as a signal recruiting macrophages to apoptotic cells.  PNX1 activation requires cleavage of its C-terminal tail by caspase<ref>PMID:22311983</ref>.
 == Relevance ==
@@ Line 11: / Line 11: @@
 == Structural highlights ==
-The 3D structure of human <scene name='91/916893/Cv/3'>PNX1 shows the pore to constitute 7 subunits</scene>. The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1.  The pore transmembrane domains are occupied by lipid molecules which interact with hydrophobic sidechains<ref>PMID:35133866</ref>.
+The 3D structure of human <scene name='91/916893/Cv/3'>PNX1 shows the pore to constitute 7 subunits</scene>. The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1. The pore transmembrane domains are occupied by <scene name='91/916893/Cv/4'>lipid molecules</scene> which interact with hydrophobic sidechains<ref>PMID:35133866</ref>.