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==Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.==
==Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.==
<StructureSection load='3tzf' size='340' side='right' caption='[[3tzf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3tzf' size='340' side='right'caption='[[3tzf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tzf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZF FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=08D:SULFAMETHOXAZOLE'>08D</scene>, <scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08D:SULFAMETHOXAZOLE'>08D</scene>, <scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tyu|3tyu]], [[3tyz|3tyz]], [[3tzn|3tzn]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tyu|3tyu]], [[3tyz|3tyz]], [[3tzn|3tzn]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzf OCA], [http://pdbe.org/3tzf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tzf RCSB], [http://www.ebi.ac.uk/pdbsum/3tzf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzf OCA], [https://pdbe.org/3tzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzf RCSB], [https://www.ebi.ac.uk/pdbsum/3tzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q7CKJ1_YERPE Q7CKJ1_YERPE]] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]  
[[https://www.uniprot.org/uniprot/Q7CKJ1_YERPE Q7CKJ1_YERPE]] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Dihydropteroate synthase|Dihydropteroate synthase]]
*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Dihydropteroate synthase]]
[[Category: Dihydropteroate synthase]]
[[Category: Large Structures]]
[[Category: Wu, Y]]
[[Category: Wu, Y]]
[[Category: Sulfonamide complex]]
[[Category: Sulfonamide complex]]
Retrieved from "https://proteopedia.org/3tzf"