3v69: Difference between revisions

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==Filia-N crystal structure==
==Filia-N crystal structure==
<StructureSection load='3v69' size='340' side='right' caption='[[3v69]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3v69' size='340' side='right'caption='[[3v69]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3v69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V69 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3v69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V69 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BL6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v69 OCA], [http://pdbe.org/3v69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v69 RCSB], [http://www.ebi.ac.uk/pdbsum/3v69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v69 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v69 OCA], [https://pdbe.org/3v69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v69 RCSB], [https://www.ebi.ac.uk/pdbsum/3v69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v69 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE]] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref>   
[[https://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE]] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Li, L]]
[[Category: Li, L]]
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