3n6q: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[3n6q]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3N6Q FirstGlance]. <br>

<table><tr><td colspan='2'>[[3n6q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N6Q FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6q OCA], [~~http~~://pdbe.org/3n6q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n6q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n6q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6q ProSAT]</span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6q OCA], [https://pdbe.org/3n6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n6q RCSB], [https://www.ebi.ac.uk/pdbsum/3n6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6q ProSAT]</span></td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/GPR_ECOLI GPR_ECOLI]] Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.<ref>PMID:12583903</ref> <ref>PMID:16077126</ref> <ref>PMID:18620424</ref>

[[https://www.uniprot.org/uniprot/GPR_ECOLI GPR_ECOLI]] Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.<ref>PMID:12583903</ref> <ref>PMID:16077126</ref> <ref>PMID:18620424</ref>

== Publication Abstract from PubMed ==

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 <StructureSection load='3n6q' size='340' side='right'caption='[[3n6q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3n6q]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3N6Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3n6q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N6Q FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6q OCA], [http://pdbe.org/3n6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n6q RCSB], [http://www.ebi.ac.uk/pdbsum/3n6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6q ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6q OCA], [https://pdbe.org/3n6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n6q RCSB], [https://www.ebi.ac.uk/pdbsum/3n6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6q ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GPR_ECOLI GPR_ECOLI]] Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.<ref>PMID:12583903</ref> <ref>PMID:16077126</ref> <ref>PMID:18620424</ref>
+[[https://www.uniprot.org/uniprot/GPR_ECOLI GPR_ECOLI]] Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.<ref>PMID:12583903</ref> <ref>PMID:16077126</ref> <ref>PMID:18620424</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==