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==Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae==
==Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae==
<StructureSection load='3vxd' size='340' side='right' caption='[[3vxd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3vxd' size='340' side='right'caption='[[3vxd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vxd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stra3 Stra3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VXD FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vxd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Stra3 Stra3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VXD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zzr|2zzr]], [[3ani|3ani]], [[3anj|3anj]], [[3ank|3ank]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zzr|2zzr]], [[3ani|3ani]], [[3anj|3anj]], [[3ank|3ank]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gbs1889 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211110 STRA3])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gbs1889 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211110 STRA3])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxd OCA], [http://pdbe.org/3vxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vxd RCSB], [http://www.ebi.ac.uk/pdbsum/3vxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxd OCA], [https://pdbe.org/3vxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vxd RCSB], [https://www.ebi.ac.uk/pdbsum/3vxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UCDH_STRA3 UCDH_STRA3]] Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.<ref>PMID:19416976</ref> <ref>PMID:21147778</ref>   
[[https://www.uniprot.org/uniprot/UCDH_STRA3 UCDH_STRA3]] Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.<ref>PMID:19416976</ref> <ref>PMID:21147778</ref>   
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Stra3]]
[[Category: Stra3]]
[[Category: Hashimoto, W]]
[[Category: Hashimoto, W]]
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