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==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==
==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==
<StructureSection load='3wro' size='340' side='right' caption='[[3wro]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
<StructureSection load='3wro' size='340' side='right'caption='[[3wro]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mumip Mumip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WRO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3wro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mumip Mumip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pp4|4pp4]], [[3wrn|3wrn]], [[3wrq|3wrq]], [[3wrr|3wrr]], [[3wrs|3wrs]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4pp4|4pp4]], [[3wrn|3wrn]], [[3wrq|3wrq]], [[3wrr|3wrr]], [[3wrs|3wrs]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=648235 MUMIP])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=648235 MUMIP])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wro OCA], [http://pdbe.org/3wro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wro RCSB], [http://www.ebi.ac.uk/pdbsum/3wro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wro ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wro OCA], [https://pdbe.org/3wro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wro RCSB], [https://www.ebi.ac.uk/pdbsum/3wro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wro ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP]] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>   
[[https://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP]] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mumip]]
[[Category: Mumip]]
[[Category: Tang, L]]
[[Category: Tang, L]]
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