SARM1

spinqualitylabelsall models Human SARM1 complex with NAD(+) (PDB ID 7cm6). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function SARM1 or NAD(+) hydrolase or sterile alpha and TIR motif-containing protein 1 or NADase is a NAD-cleaving enzyme whose activation triggers axon destruction. SARM1 is a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise. SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis. Disease SARM1 mutations were found in ALS patients. Structural highlights The 3D structure of SARM1 shows the octamer structure with outer ring dimension of 200A, inner ring of 45A and thickness of 60A. The 3 domains of SARM1 are ARM, SAM and TIR. The interaction of the ARM and TIR domains cause the autoinhibition of SARM1. NAD(+) binding pocket is at the concave side of the ARM domain. 3D structures of SARM1 SARM1 3D structures

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