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==VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP==
==VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP==
<StructureSection load='3zc7' size='340' side='right' caption='[[3zc7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3zc7' size='340' side='right'caption='[[3zc7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_schoenbuchensis Bartonella schoenbuchensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZC7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bartonella_schoenbuchensis Bartonella schoenbuchensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZC7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zc7 OCA], [http://pdbe.org/3zc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zc7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zc7 OCA], [https://pdbe.org/3zc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zc7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VBHT_BARSR VBHT_BARSR]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[http://www.uniprot.org/uniprot/VBHA_BARSR VBHA_BARSR]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.  
[[https://www.uniprot.org/uniprot/VBHT_BARSR VBHT_BARSR]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[https://www.uniprot.org/uniprot/VBHA_BARSR VBHA_BARSR]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Bartonella schoenbuchensis]]
[[Category: Bartonella schoenbuchensis]]
[[Category: Large Structures]]
[[Category: Goepfert, A]]
[[Category: Goepfert, A]]
[[Category: Schirmer, T]]
[[Category: Schirmer, T]]
Retrieved from "https://proteopedia.org/3zc7"