3zcb: Difference between revisions
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==VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin mutant E24G and ATP== | ==VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin mutant E24G and ATP== | ||
<StructureSection load='3zcb' size='340' side='right' caption='[[3zcb]], [[Resolution|resolution]] 1.94Å' scene=''> | <StructureSection load='3zcb' size='340' side='right'caption='[[3zcb]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zcb]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3zcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bartonella_schoenbuchensis Bartonella schoenbuchensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZCB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zc7|3zc7]], [[3zcn|3zcn]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zc7|3zc7]], [[3zcn|3zcn]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcb OCA], [https://pdbe.org/3zcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zcb RCSB], [https://www.ebi.ac.uk/pdbsum/3zcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/VBHT_BARSR VBHT_BARSR]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[https://www.uniprot.org/uniprot/VBHA_BARSR VBHA_BARSR]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bartonella schoenbuchensis]] | [[Category: Bartonella schoenbuchensis]] | ||
[[Category: Large Structures]] | |||
[[Category: Goepfert, A]] | [[Category: Goepfert, A]] | ||
[[Category: Schirmer, T]] | [[Category: Schirmer, T]] | ||
