3zq4: Difference between revisions

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<StructureSection load='3zq4' size='340' side='right'caption='[[3zq4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3zq4' size='340' side='right'caption='[[3zq4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zq4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQ4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zq4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQ4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zq4 OCA], [http://pdbe.org/3zq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zq4 RCSB], [http://www.ebi.ac.uk/pdbsum/3zq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zq4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zq4 OCA], [https://pdbe.org/3zq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zq4 RCSB], [https://www.ebi.ac.uk/pdbsum/3zq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zq4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RNJ1_BACSU RNJ1_BACSU]] An RNase that has endonuclease and 5'-3' exonuclease activity, playing a role in both rRNA and mRNA stability and degradation. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Endonuclease digestion by the RNase J1/J2 complex occurs at a different site and in some cases more efficiently than J1 or J2 alone. The exonuclease activity of the J1/J2 complex is highly processive on substrates longer than 5 nucleotides, on shorter substrates is distributive. Preferentially cleaves ssRNA, possibly in AU-rich regions. The 5'-exonuclease activity acts on 5'-hydroxyl and 5'-monophosphate but not 5'-triphosphate ends; it can digest through stem-loop structures if they are not too stable. Required for maturation of 16S rRNA. Acts preferentially on 16S rRNA precursors after association of the 30S and 50S ribosomal subunits. Plays a role in the secondary pathway of 23S rRNA 5' end maturation. Probably also participates in processing of pre-scRNA (the precursor of the signal recognition particle RNA).<ref>PMID:15831787</ref> <ref>PMID:17229210</ref> <ref>PMID:17512403</ref> <ref>PMID:17576666</ref> <ref>PMID:18204464</ref> <ref>PMID:18445592</ref> <ref>PMID:18713320</ref> <ref>PMID:19880604</ref> <ref>PMID:20025672</ref> <ref>PMID:21893286</ref> <ref>PMID:22014150</ref> <ref>PMID:22412379</ref> <ref>PMID:23504012</ref>   
[[https://www.uniprot.org/uniprot/RNJ1_BACSU RNJ1_BACSU]] An RNase that has endonuclease and 5'-3' exonuclease activity, playing a role in both rRNA and mRNA stability and degradation. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Endonuclease digestion by the RNase J1/J2 complex occurs at a different site and in some cases more efficiently than J1 or J2 alone. The exonuclease activity of the J1/J2 complex is highly processive on substrates longer than 5 nucleotides, on shorter substrates is distributive. Preferentially cleaves ssRNA, possibly in AU-rich regions. The 5'-exonuclease activity acts on 5'-hydroxyl and 5'-monophosphate but not 5'-triphosphate ends; it can digest through stem-loop structures if they are not too stable. Required for maturation of 16S rRNA. Acts preferentially on 16S rRNA precursors after association of the 30S and 50S ribosomal subunits. Plays a role in the secondary pathway of 23S rRNA 5' end maturation. Probably also participates in processing of pre-scRNA (the precursor of the signal recognition particle RNA).<ref>PMID:15831787</ref> <ref>PMID:17229210</ref> <ref>PMID:17512403</ref> <ref>PMID:17576666</ref> <ref>PMID:18204464</ref> <ref>PMID:18445592</ref> <ref>PMID:18713320</ref> <ref>PMID:19880604</ref> <ref>PMID:20025672</ref> <ref>PMID:21893286</ref> <ref>PMID:22014150</ref> <ref>PMID:22412379</ref> <ref>PMID:23504012</ref>   
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Ribonuclease|Ribonuclease]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
*[[Temp|Temp]]
== References ==
== References ==
<references/>
<references/>
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