4jdy

Crystal structure of Rv2606c

spinqualitylabelsall models 4jdy, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4jdy is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL Related: 2iss, 2zbt Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PDXS_MYCTU] Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity). Publication Abstract from PubMed Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. We determined the crystal structure of Rv2606c, a potential pyridoxal biosynthesis lyase (PdxS), from M. tuberculosis H37Rv at 1.8A resolution. The overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, was quite similar to those of other PdxS proteins. A glycerol molecule was observed to be bound at the active site of the Rv2606c structure through interactions with the conserved residues of Asp29 and Lys86, providing information regarding the potential active site and the substrate-binding environment of the protein. The interface for Rv2606c dodecamerization, which is primarily mediated by salt bridges and hydrophobic interactions, was quite different from those of other PdxS proteins. Furthermore, we observed that the Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as PdxS and PdxT in M. tuberculosis. Crystal structure of Mycobacterium tuberculosis Rv2606c: A pyridoxal biosynthesis lyase.,Kim S, Kim KJ Biochem Biophys Res Commun. 2013 May 31;435(2):255-9. doi:, 10.1016/j.bbrc.2013.04.068. Epub 2013 Apr 30. PMID:23643787 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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