4ani: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4ani' size='340' side='right'caption='[[4ani]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
<StructureSection load='4ani' size='340' side='right'caption='[[4ani]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geoka Geoka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geoka Geoka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANI FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v7y|2v7y]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v7y|2v7y]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [http://pdbe.org/4ani PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [http://www.ebi.ac.uk/pdbsum/4ani PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ani ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [https://pdbe.org/4ani PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [https://www.ebi.ac.uk/pdbsum/4ani PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ani ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity). [[http://www.uniprot.org/uniprot/DNAK_GEOKA DNAK_GEOKA]] Acts as a chaperone (By similarity).  
[[https://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity). [[https://www.uniprot.org/uniprot/DNAK_GEOKA DNAK_GEOKA]] Acts as a chaperone (By similarity).  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 20:


==See Also==
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
Line 26: Line 26:
</StructureSection>
</StructureSection>
[[Category: Geoka]]
[[Category: Geoka]]
[[Category: Large Structures]]
[[Category: Chang, Y W]]
[[Category: Chang, Y W]]
[[Category: Chien, C H]]
[[Category: Chien, C H]]
Retrieved from "https://proteopedia.org/4ani"