4bn5: Difference between revisions

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<StructureSection load='4bn5' size='340' side='right'caption='[[4bn5]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
<StructureSection load='4bn5' size='340' side='right'caption='[[4bn5]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bn5]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BN5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BN5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bn5]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BN5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SR7:N-{2-[3-(PIPERAZIN-1-YLMETHYL)IMIDAZO[2,1-B][1,3]THIAZOL-6-YL]PHENYL}QUINOXALINE-2-CARBOXAMIDE'>SR7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SR7:N-{2-[3-(PIPERAZIN-1-YLMETHYL)IMIDAZO[2,1-B][1,3]THIAZOL-6-YL]PHENYL}QUINOXALINE-2-CARBOXAMIDE'>SR7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bn4|4bn4]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bn4|4bn4]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bn5 OCA], [http://pdbe.org/4bn5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bn5 RCSB], [http://www.ebi.ac.uk/pdbsum/4bn5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bn5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bn5 OCA], [https://pdbe.org/4bn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bn5 RCSB], [https://www.ebi.ac.uk/pdbsum/4bn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bn5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>   
[[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>   
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Retrieved from "https://proteopedia.org/4bn5"