4bqj: Difference between revisions
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<StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQJ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bqg|4bqg]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bqg|4bqg]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [https://pdbe.org/4bqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [https://www.ebi.ac.uk/pdbsum/4bqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 07:22, 31 August 2022
structure of HSP90 with an inhibitor bound
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