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==Mn2+-GMP complex of nanoRNase (Nrn) from Bacteroides fragilis==
==Mn2+-GMP complex of nanoRNase (Nrn) from Bacteroides fragilis==
<StructureSection load='3w5w' size='340' side='right'caption='[[3w5w]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='3w5w' size='340' side='right'caption='[[3w5w]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3w5w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W5W FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W5W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w5w OCA], [https://pdbe.org/3w5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w5w RCSB], [https://www.ebi.ac.uk/pdbsum/3w5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w5w ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dma|3dma]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w5w OCA], [https://pdbe.org/3w5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w5w RCSB], [https://www.ebi.ac.uk/pdbsum/3w5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w5w ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
NanoRNase (Nrn) specifically degrades nucleoside 3',5'-bisphosphate and the very short RNA, nanoRNA, during the final step of mRNA degradation. The crystal structure of Nrn in complex with a reaction product GMP was determined. The overall structure consists of two domains that are interconnected by a flexible loop and form a cleft. Two Mn(2)(+) ions are coordinated by conserved residues in the DHH motif of the N-terminal domain. GMP binds near the DHHA1 motif region in the C-terminal domain. Our structure enables us to predict the substrate-bound form of Nrn as well as other DHH/DHHA1 phosphoesterase family proteins.
Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins.,Uemura Y, Nakagawa N, Wakamatsu T, Kim K, Montelione GT, Hunt JF, Kuramitsu S, Masui R FEBS Lett. 2013 Aug 19;587(16):2669-74. doi: 10.1016/j.febslet.2013.06.053. Epub , 2013 Jul 9. PMID:23851074<ref>PMID:23851074</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3w5w" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hunt, J F]]
[[Category: Hunt JF]]
[[Category: Kuramitsu, S]]
[[Category: Kuramitsu S]]
[[Category: Masui, R]]
[[Category: Masui R]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Nakagawa, N]]
[[Category: Nakagawa N]]
[[Category: Uemura, Y]]
[[Category: Uemura Y]]
[[Category: Wakamatsu, T]]
[[Category: Wakamatsu T]]
[[Category: Dhh phosphatase]]
[[Category: Dhha1 motif]]
[[Category: Hydrolase]]
[[Category: Phosphatase]]

Revision as of 10:28, 31 August 2022

Mn2+-GMP complex of nanoRNase (Nrn) from Bacteroides fragilis

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