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==Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH==
==Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH==
<StructureSection load='3wg6' size='340' side='right'caption='[[3wg6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3wg6' size='340' side='right'caption='[[3wg6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wg6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG6 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg6 OCA], [https://pdbe.org/3wg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg6 OCA], [https://pdbe.org/3wg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg6 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 is a member of the aldo-keto reductase (AKR) superfamily and reduces ketopantoyl lactone to D-pantoyl lactone in a NADPH-dependent and stereospecific manner. We determined the crystal structure of CPR-C1.NADPH complex at 2.20 A resolution. CPR-C1 adopted a triose-phosphate isomerase (TIM) barrel fold at the core of the structure in which Thr25 and Lys26 of the GXGTX motif bind uniquely to the adenosine 2'-phosphate group of NADPH. This finding provides a novel structural basis for NADPH binding of the AKR superfamily. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc.
Crystal structure of conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 complexed with NADPH.,Qin HM, Yamamura A, Miyakawa T, Kataoka M, Maruoka S, Ohtsuka J, Nagata K, Shimizu S, Tanokura M Proteins. 2013 Jul 15. doi: 10.1002/prot.24363. PMID:23852710<ref>PMID:23852710</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3wg6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kataoka, M]]
[[Category: Kataoka M]]
[[Category: Maruoka, S]]
[[Category: Maruoka S]]
[[Category: Miyakawa, T]]
[[Category: Miyakawa T]]
[[Category: Nagata, K]]
[[Category: Nagata K]]
[[Category: Ohtsuka, J]]
[[Category: Ohtsuka J]]
[[Category: Qin, H M]]
[[Category: Qin H-M]]
[[Category: Shimizu, S]]
[[Category: Shimizu S]]
[[Category: Tanokura, M]]
[[Category: Tanokura M]]
[[Category: Yamamura, A]]
[[Category: Yamamura A]]
[[Category: Akr superfamily]]
[[Category: D-pantoyl lactone]]
[[Category: Oxidoreductase]]
[[Category: Tim barrel]]

Revision as of 10:30, 31 August 2022

Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH

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