4l9a: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
Line 1: Line 1:


==Crystal structure of Smu.1393c from cariogenic pathogen Streptococcus mutans==
==Crystal structure of Smu.1393c from cariogenic pathogen Streptococcus mutans==
<StructureSection load='4l9a' size='340' side='right'caption='[[4l9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4l9a' size='340' side='right'caption='[[4l9a]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l9a]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l80 3l80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9A FirstGlance]. <br>
<table><tr><td colspan='2'>This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l80 3l80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9a OCA], [https://pdbe.org/4l9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9a RCSB], [https://www.ebi.ac.uk/pdbsum/4l9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9a ProSAT]</span></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9a OCA], [https://pdbe.org/4l9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9a RCSB], [https://www.ebi.ac.uk/pdbsum/4l9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9a ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The protein Smu.1393c from Streptococcus mutans is annotated as a putative alpha/beta hydrolase, but it has low sequence identity to the structure-known alpha/beta hydrolases. Here we present the crystal structure of Smu.1393c at 2.0 A resolution. Smu.1393c has a fully open alkaline substrate pocket, whose conformation is unique among other similar hydrolase structures. Three residues, Ser101, His251, and Glu125, were identified as the active center of Smu.1393c. By screening a series of artificial hydrolase substrates, we demonstrated Smu.1393c had low carboxylesterase activity towards short-chain carboxyl esters, which provided a clue for exploring the in vivo function of Smu.1393c. Proteins 2013; (c) 2013 Wiley Periodicals, Inc.
Structural and functional characterization of a novel alpha/beta hydrolase from cariogenic pathogen Streptococcus mutans.,Wang Z, Li L, Su XD Proteins. 2013 Sep 30. doi: 10.1002/prot.24418. PMID:24115105<ref>PMID:24115105</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4l9a" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Li, L]]
[[Category: Li L]]
[[Category: Su, X D]]
[[Category: Su X-D]]
[[Category: Wang, Z]]
[[Category: Wang Z]]
[[Category: Alpha/beta hydrolase]]
[[Category: Carboxylesterase]]
[[Category: Hydrolase]]

Latest revision as of 10:46, 31 August 2022

Crystal structure of Smu.1393c from cariogenic pathogen Streptococcus mutans

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=4l9a&oldid=3613702"