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==Crystal structure of thioredoxin 2 from Staphylococcus aureus NCTC8325==
==Crystal structure of thioredoxin 2 from Staphylococcus aureus NCTC8325==
<StructureSection load='4ruv' size='340' side='right'caption='[[4ruv]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='4ruv' size='340' side='right'caption='[[4ruv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ruv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUV FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUV FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ruv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ruv OCA], [https://pdbe.org/4ruv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ruv RCSB], [https://www.ebi.ac.uk/pdbsum/4ruv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ruv ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ruv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ruv OCA], [https://pdbe.org/4ruv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ruv RCSB], [https://www.ebi.ac.uk/pdbsum/4ruv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ruv ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The redox homeostasis of cytoplasm is maintained by a series of disulfide exchange reactions mediated by proteins belonging to the thioredoxin superfamily. Thioredoxin and thioredoxin reductase, being the major members of the family, play a key role in oxidative stress response of Staphylococcus aureus. In this report, we have identified and characterised an active thioredoxin system of the mentioned pathogen. Crystal structure of thioredoxin2 (SaTrx2) in its reduced form reveals that it contains the conserved redox active WCXXC motif and a thioredoxin fold. Thioredoxin reductase2 (SaTR2) is a flavoprotein and consists of two Rossmann folds as the binding sites for FAD and NADPH. Crystal structure of the SaTR2 holoenzyme shows that the protein consists of two domains and the catalytic site comprises of an intramolecular disulfide bond formed between two sequentially distal cysteine residues. Biophysical and biochemical studies unveil that SaTrx2 and SaTR2 can physically interact in solution and in the course of sustaining the redox equilibrium, the latter reduces the former. Molecular docking has been performed to illustrate the interface formed between SaTrx2 and SaTR2 during the disulfide exchange reaction.
Elucidation of the mechanism of disulfide exchange between staphylococcal thioredoxin2 and thioredoxin reductase2: A structural insight.,Bose M, Bhattacharyya S, Biswas R, Roychowdhury A, Bhattacharjee A, Ghosh AK, Das AK Biochimie. 2019 Jan 31;160:1-13. doi: 10.1016/j.biochi.2019.01.019. PMID:30710560<ref>PMID:30710560</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ruv" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bhattacharyya, S]]
[[Category: Bhattacharyya S]]
[[Category: Biswas, R]]
[[Category: Biswas R]]
[[Category: Bose, M]]
[[Category: Bose M]]
[[Category: Das, A K]]
[[Category: Das AK]]
[[Category: Ghosh, A K]]
[[Category: Ghosh AK]]
[[Category: Roychowdhury, A]]
[[Category: Roychowdhury A]]
[[Category: Electron transport]]
[[Category: Oxidoreductase]]

Revision as of 11:00, 31 August 2022

Crystal structure of thioredoxin 2 from Staphylococcus aureus NCTC8325

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