7phj: Difference between revisions

==LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria==

<table><tr><td colspan='2'>[[7phj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PHJ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PX:(2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide'>7PX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7phj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7phj OCA], [https://pdbe.org/7phj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7phj RCSB], [https://www.ebi.ac.uk/pdbsum/7phj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7phj ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/LPXC_ECOLI LPXC_ECOLI]] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.[HAMAP-Rule:MF_00388]<ref>PMID:10026271</ref> <ref>PMID:8530464</ref> <ref>PMID:8824222</ref> <ref>PMID:18289052</ref>

[[Category: Lamers MBAC]]

[[Category: Leonard PM]]

[[Category: Ryan MD]]