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'''Unreleased structure'''


The entry 8agi is ON HOLD  until Paper Publication
==Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with JMC31==
 
<StructureSection load='8agi' size='340' side='right'caption='[[8agi]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Tassone, G., Pozzi, C., Mazzorana, M., Mangani, S., Maramai, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8agi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AGI FirstGlance]. <br>
Description: Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with JMC31
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0U:1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide'>M0U</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8agi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8agi OCA], [https://pdbe.org/8agi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8agi RCSB], [https://www.ebi.ac.uk/pdbsum/8agi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8agi ProSAT]</span></td></tr>
[[Category: Maramai, S]]
</table>
[[Category: Tassone, G]]
== Function ==
[[Category: Mangani, S]]
[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
[[Category: Pozzi, C]]
== References ==
[[Category: Mazzorana, M]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mangani S]]
[[Category: Maramai S]]
[[Category: Mazzorana M]]
[[Category: Pozzi C]]
[[Category: Tassone G]]
Retrieved from "https://proteopedia.org/8agi"