7soo: Difference between revisions
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==LaM domain of human LARP1== | ==LaM domain of human LARP1== | ||
<StructureSection load='7soo' size='340' side='right'caption='[[7soo]]' scene=''> | <StructureSection load='7soo' size='340' side='right'caption='[[7soo]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SOO FirstGlance]. <br> | <table><tr><td colspan='2'>[[7soo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SOO FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7soo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7soo OCA], [https://pdbe.org/7soo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7soo RCSB], [https://www.ebi.ac.uk/pdbsum/7soo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7soo ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7soo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7soo OCA], [https://pdbe.org/7soo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7soo RCSB], [https://www.ebi.ac.uk/pdbsum/7soo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7soo ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/LARP1_HUMAN LARP1_HUMAN]] RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation.<ref>PMID:20430826</ref> <ref>PMID:23711370</ref> <ref>PMID:24532714</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gehring K]] | [[Category: Gehring K]] | ||
[[Category: Kozlov G]] | [[Category: Kozlov G]] | ||
