7vou: Difference between revisions
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==The crystal structure of human forkhead box protein in complex with DNA 1== | ==The crystal structure of human forkhead box protein in complex with DNA 1== | ||
<StructureSection load='7vou' size='340' side='right'caption='[[7vou]]' scene=''> | <StructureSection load='7vou' size='340' side='right'caption='[[7vou]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOU FirstGlance]. <br> | <table><tr><td colspan='2'>[[7vou]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vou OCA], [https://pdbe.org/7vou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vou RCSB], [https://www.ebi.ac.uk/pdbsum/7vou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vou ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vou OCA], [https://pdbe.org/7vou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vou RCSB], [https://www.ebi.ac.uk/pdbsum/7vou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vou ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Choi Y]] | [[Category: Choi Y]] | ||
[[Category: Lee HH]] | [[Category: Lee HH]] | ||
[[Category: Yoon HJ]] | [[Category: Yoon HJ]] | ||
