7z9l: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z9l OCA], [https://pdbe.org/7z9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z9l RCSB], [https://www.ebi.ac.uk/pdbsum/7z9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z9l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z9l OCA], [https://pdbe.org/7z9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z9l RCSB], [https://www.ebi.ac.uk/pdbsum/7z9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z9l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
Human telomeric G-quadruplex DNA structures are attractive anticancer drug targets, but the target's polymorphism complicates the drug design: different ligands prefer different folds, and very few complexes have been solved at high resolution. Here we report that Phen-DC3 , one of the most prominent G-quadruplex ligands in terms of high binding affinity and selectivity, causes dTAGGG(TTAGGG)3 to completely change its fold in KCl solution from a hybrid-1 to an antiparallel chair-type structure, wherein the ligand intercalates between a two-quartet unit and a pseudo-quartet, thereby ejecting one potassium ion. This unprecedented high-resolution NMR structure shows for the first time a true ligand intercalation into an intramolecular G-quadruplex. | |||
Phen-DC3 Induces Refolding of Human Telomeric DNA into a Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation.,Ghosh A, Trajkovski M, Teulade-Fichou MP, Gabelica V, Plavec J Angew Chem Int Ed Engl. 2022 Aug 22:e202207384. doi: 10.1002/anie.202207384. PMID:35993443<ref>PMID:35993443</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 7z9l" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 19:01, 7 September 2022
Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex
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