8a43: Difference between revisions
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==== | ==Human RNA polymerase I== | ||
<StructureSection load='8a43' size='340' side='right'caption='[[8a43]]' scene=''> | <StructureSection load='8a43' size='340' side='right'caption='[[8a43]], [[Resolution|resolution]] 4.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[8a43]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A43 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a43 OCA], [https://pdbe.org/8a43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a43 RCSB], [https://www.ebi.ac.uk/pdbsum/8a43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a43 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a43 OCA], [https://pdbe.org/8a43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a43 RCSB], [https://www.ebi.ac.uk/pdbsum/8a43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a43 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/RPA2_HUMAN RPA2_HUMAN]] Treacher-Collins syndrome. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/RPA2_HUMAN RPA2_HUMAN]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.<ref>PMID:16809778</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Abascal-Palacios G]] | ||
[[Category: Bernecky C]] | |||
[[Category: Bleckmann A]] | |||
[[Category: Bruckmann A]] | |||
[[Category: Daiss JL]] | |||
[[Category: Engel C]] | |||
[[Category: Fuertges T]] | |||
[[Category: Heiss FB]] | |||
[[Category: Hoecherl M]] | |||
[[Category: Lamour V]] | |||
[[Category: Mars JC]] | |||
[[Category: Moss T]] | |||
[[Category: Panov K]] | |||
[[Category: Pilsl M]] | |||
[[Category: Ramsay E]] | |||
[[Category: Rudack T]] | |||
[[Category: Straub K]] | |||
[[Category: Tluckova K]] | |||
[[Category: Vannini A]] | |||
