7y12: Difference between revisions
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==== | ==Cryo-EM structure of MrgD-Gi complex with beta-alanine== | ||
<StructureSection load='7y12' size='340' side='right'caption='[[7y12]]' scene=''> | <StructureSection load='7y12' size='340' side='right'caption='[[7y12]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7y12]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y12 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y12 OCA], [https://pdbe.org/7y12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y12 RCSB], [https://www.ebi.ac.uk/pdbsum/7y12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y12 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y12 OCA], [https://pdbe.org/7y12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y12 RCSB], [https://www.ebi.ac.uk/pdbsum/7y12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y12 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Synthetic construct]] | |||
[[Category: Iida M]] | |||
[[Category: Kawamoto A]] | |||
[[Category: Oshima A]] | |||
[[Category: Suzuki S]] | |||
Revision as of 05:04, 8 September 2022
Cryo-EM structure of MrgD-Gi complex with beta-alanine
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