7z3j: Difference between revisions
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==Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate== | ==Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate== | ||
<StructureSection load='7z3j' size='340' side='right'caption='[[7z3j]]' scene=''> | <StructureSection load='7z3j' size='340' side='right'caption='[[7z3j]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z3J FirstGlance]. <br> | <table><tr><td colspan='2'>[[7z3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z3J FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z3j OCA], [https://pdbe.org/7z3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z3j RCSB], [https://www.ebi.ac.uk/pdbsum/7z3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z3j ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z3j OCA], [https://pdbe.org/7z3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z3j RCSB], [https://www.ebi.ac.uk/pdbsum/7z3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z3j ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/PLCG1_RAT PLCG1_RAT]] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Bunney TD]] | [[Category: Bunney TD]] | ||
[[Category: Katan M]] | [[Category: Katan M]] | ||
[[Category: Pinotsis N]] | [[Category: Pinotsis N]] | ||
