7z50: Difference between revisions
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==Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.== | ==Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.== | ||
<StructureSection load='7z50' size='340' side='right'caption='[[7z50]]' scene=''> | <StructureSection load='7z50' size='340' side='right'caption='[[7z50]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7z50]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/HA2D_MOUSE HA2D_MOUSE]] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We recently provided evidence for promiscuous recognition of several different hybrid insulin peptides (HIPs) by the highly diabetogenic, I-A(g7)-restricted 4.1-T cell receptor (TCR). To understand the structural determinants of this phenomenon, we solved the structure of an agonistic HIP/I-A(g7) complex, both in isolation as well as bound to the 4.1-TCR. We find that HIP promiscuity of the 4.1-TCR is dictated, on the one hand, by an amino acid sequence pattern that ensures I-A(g7) binding and, on the other hand, by the presence of three acidic residues at positions P5, P7 and P8 that favor an optimal engagement by the 4.1-TCR's complementary determining regions. Surprisingly, comparison of the TCR-bound and unbound HIP/I-A(g7) structures reveals that 4.1-TCR binding triggers several novel and unique structural motions in both the I-A(g7) molecule and the peptide that are essential for docking. This observation indicates that the type 1 diabetes-associated I-A(g7) molecule is structurally malleable and that this plasticity allows the recognition of multiple peptides by individual TCRs that would otherwise be unable to do so. | |||
Structural plasticity in I-A(g7) links autoreactivity to hybrid insulin peptides in type I diabetes.,Erausquin E, Serra P, Parras D, Santamaria P, Lopez-Sagaseta J Front Immunol. 2022 Jul 28;13:924311. doi: 10.3389/fimmu.2022.924311. eCollection, 2022. PMID:35967292<ref>PMID:35967292</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7z50" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Erausquin E]] | [[Category: Erausquin E]] | ||
[[Category: Lopez-Sagaseta J]] | [[Category: Lopez-Sagaseta J]] | ||
Revision as of 05:05, 8 September 2022
Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.
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