7zyi: Difference between revisions
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==== | ==Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody== | ||
<StructureSection load='7zyi' size='340' side='right'caption='[[7zyi]]' scene=''> | <StructureSection load='7zyi' size='340' side='right'caption='[[7zyi]], [[Resolution|resolution]] 2.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7zyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYI FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyi OCA], [https://pdbe.org/7zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyi RCSB], [https://www.ebi.ac.uk/pdbsum/7zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyi ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyi OCA], [https://pdbe.org/7zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyi RCSB], [https://www.ebi.ac.uk/pdbsum/7zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyi ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Lama glama]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Agrawal P]] | |||
[[Category: Bang-Sorensen R]] | |||
[[Category: Irobalieva RN]] | |||
[[Category: Kossiakoff AA]] | |||
[[Category: Liu H]] | |||
[[Category: Locher KP]] | |||
[[Category: Mukherjee S]] | |||
[[Category: Nosol K]] | |||
[[Category: Stieger B]] | |||
Revision as of 05:35, 8 September 2022
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
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