7p0w: Difference between revisions

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====

==Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing thymine opposite to lesion)==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance].

<table><tr><td colspan='2'>[[7p0w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P0W OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7P0W FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0w OCA], [https://pdbe.org/7p0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0w RCSB], [https://www.ebi.ac.uk/pdbsum/7p0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0w ProSAT]</td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PED:PENTANE-3,4-DIOL-5-PHOSPHATE'>PED</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0w OCA], [https://pdbe.org/7p0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0w RCSB], [https://www.ebi.ac.uk/pdbsum/7p0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0w ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/AGOG_PYRAB AGOG_PYRAB]] DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: ~~Z-disk~~]]

[[Category: Pyrococcus abyssi GE5]]

[[Category: Synthetic construct]]

[[Category: Castaing B]]

[[Category: Coste F]]

[[Category: Flament D]]

[[Category: Goffinont S]]

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-====
+==Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing thymine opposite to lesion)==
-<StructureSection load='7p0w' size='340' side='right'caption='[[7p0w]]' scene=''>
+<StructureSection load='7p0w' size='340' side='right'caption='[[7p0w]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7p0w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P0W FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0w OCA], [https://pdbe.org/7p0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0w RCSB], [https://www.ebi.ac.uk/pdbsum/7p0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0w ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PED:PENTANE-3,4-DIOL-5-PHOSPHATE'>PED</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0w OCA], [https://pdbe.org/7p0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0w RCSB], [https://www.ebi.ac.uk/pdbsum/7p0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0w ProSAT]</span></td></tr>
 </table>
+== Function ==
+[[https://www.uniprot.org/uniprot/AGOG_PYRAB AGOG_PYRAB]] DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Pyrococcus abyssi GE5]]
+[[Category: Synthetic construct]]
+[[Category: Castaing B]]
+[[Category: Coste F]]
+[[Category: Flament D]]
+[[Category: Goffinont S]]