7rh3: Difference between revisions
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==Co-crystallization of human galectin-3 CRD complex with Methyl 2-O-(2-nitro-4-chloro)-benzoyl-3-O-toluoyl-b-D-talopyranoside== | ==Co-crystallization of human galectin-3 CRD complex with Methyl 2-O-(2-nitro-4-chloro)-benzoyl-3-O-toluoyl-b-D-talopyranoside== | ||
<StructureSection load='7rh3' size='340' side='right'caption='[[7rh3]]' scene=''> | <StructureSection load='7rh3' size='340' side='right'caption='[[7rh3]], [[Resolution|resolution]] 1.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RH3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7rh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RH3 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rh3 OCA], [https://pdbe.org/7rh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rh3 RCSB], [https://www.ebi.ac.uk/pdbsum/7rh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rh3 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59O:methyl+2-O-(4-chloro-2-nitrobenzoyl)-3-O-(4-methylbenzoyl)-beta-D-talopyranoside'>59O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rh3 OCA], [https://pdbe.org/7rh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rh3 RCSB], [https://www.ebi.ac.uk/pdbsum/7rh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rh3 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blanchard H]] | [[Category: Blanchard H]] | ||
[[Category: Collins PM]] | [[Category: Collins PM]] | ||
[[Category: Kishor C]] | [[Category: Kishor C]] | ||
