7fci: Difference between revisions
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==== | ==human NTCP in complex with YN69083 Fab== | ||
<StructureSection load='7fci' size='340' side='right'caption='[[7fci]]' scene=''> | <StructureSection load='7fci' size='340' side='right'caption='[[7fci]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7fci]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCI FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fci OCA], [https://pdbe.org/7fci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fci RCSB], [https://www.ebi.ac.uk/pdbsum/7fci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fci ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fci OCA], [https://pdbe.org/7fci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fci RCSB], [https://www.ebi.ac.uk/pdbsum/7fci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fci ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Z- | [[Category: Mus musculus]] | ||
[[Category: Ishimoto N]] | |||
[[Category: Iwamoto M]] | |||
[[Category: Iwata S]] | |||
[[Category: Jin Z]] | |||
[[Category: Lee W]] | |||
[[Category: Liu K]] | |||
[[Category: Mizutani K]] | |||
[[Category: Muramatsu M]] | |||
[[Category: Nishizawa T]] | |||
[[Category: Nomura N]] | |||
[[Category: Ohki M]] | |||
[[Category: Oshima M]] | |||
[[Category: Park JH]] | |||
[[Category: Park SY]] | |||
[[Category: Shirouzu M]] | |||
[[Category: Son D]] | |||
[[Category: Tame JRH]] | |||
[[Category: Uchikubo-Kamo T]] | |||
[[Category: Uemura T]] | |||
[[Category: Wakita T]] | |||
[[Category: Watashi K]] | |||
[[Category: Yoshida H]] | |||
[[Category: Yun JH]] | |||
