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==N-terminal C2H2 Zn-finger domain of Clamp==
==N-terminal C2H2 Zn-finger domain of Clamp==
<StructureSection load='7nf9' size='340' side='right'caption='[[7nf9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='7nf9' size='340' side='right'caption='[[7nf9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7nf9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NF9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7nf9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NF9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nf9 OCA], [https://pdbe.org/7nf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nf9 RCSB], [https://www.ebi.ac.uk/pdbsum/7nf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nf9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nf9 OCA], [https://pdbe.org/7nf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nf9 RCSB], [https://www.ebi.ac.uk/pdbsum/7nf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nf9 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[[https://www.uniprot.org/uniprot/Q8IGP5_DROME Q8IGP5_DROME]]
Transcriptional regulators select their targets from a large pool of similar genomic sites. The binding of the Drosophila dosage compensation complex (DCC) exclusively to the male X chromosome provides insight into binding site selectivity rules. Previous studies showed that the male-specific organizer of the complex, MSL2, and ubiquitous DNA-binding protein CLAMP directly interact and play an important role in the specificity of X chromosome binding. Here, we studied the highly specific interaction between the intrinsically disordered region of MSL2 and the N-terminal zinc-finger C2H2-type (C2H2) domain of CLAMP. We obtained the NMR structure of the CLAMP N-terminal C2H2 zinc finger, which has a classic C2H2 zinc-finger fold with a rather unusual distribution of residues typically used in DNA recognition. Substitutions of residues in this C2H2 domain had the same effect on the viability of males and females, suggesting that it plays a general role in CLAMP activity. The N-terminal C2H2 domain of CLAMP is highly conserved in insects. However, the MSL2 region involved in the interaction is conserved only within the Drosophila genus, suggesting that this interaction emerged during the evolution of a mechanism for the specific recruitment of the DCC on the male X chromosome in Drosophilidae.
 
Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.,Tikhonova E, Mariasina S, Efimov S, Polshakov V, Maksimenko O, Georgiev P, Bonchuk A Nucleic Acids Res. 2022 Jun 24;50(11):6521-6531. doi: 10.1093/nar/gkac455. PMID:35648444<ref>PMID:35648444</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7nf9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bonchuk, A N]]
[[Category: Bonchuk AN]]
[[Category: Efimov, S V]]
[[Category: Efimov SV]]
[[Category: Georgiev, P G]]
[[Category: Georgiev PG]]
[[Category: Maksimenko, O G]]
[[Category: Maksimenko OG]]
[[Category: Mariasina, S S]]
[[Category: Mariasina SS]]
[[Category: Polshakov, V I]]
[[Category: Polshakov VI]]
[[Category: Tikhonova, E A]]
[[Category: Tikhonova EA]]
[[Category: Dosage compensation zinc finger]]
[[Category: Gene regulation]]
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