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==G-quadruplex structure of the C. elegans telomeric repeat: A two tetrads basket type conformation stabilised by a Hoogsteen C-T base-pair==
==G-quadruplex structure of the C. elegans telomeric repeat: A two tetrads basket type conformation stabilised by a Hoogsteen C-T base-pair==
<StructureSection load='7oqt' size='340' side='right'caption='[[7oqt]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='7oqt' size='340' side='right'caption='[[7oqt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7oqt]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OQT FirstGlance]. <br>
<table><tr><td colspan='2'>[[7oqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OQT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oqt OCA], [https://pdbe.org/7oqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oqt RCSB], [https://www.ebi.ac.uk/pdbsum/7oqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oqt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oqt OCA], [https://pdbe.org/7oqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oqt RCSB], [https://www.ebi.ac.uk/pdbsum/7oqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oqt ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Caenorhabditis elegans model has greatly contributed to the understanding of the role of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres resemble the GGGTTA repeats of the human telomeres. However, the comparison of telomeric sequences (Homo sapiens, Tetrahymena, Oxytricha, Bombyx mori and Giardia) revealed that small changes in these repeats can drastically change the topology of the folded G-quadruplex. In the present work we determined the structure adopted by the C. elegans telomeric sequence d[GG(CTTAGG)3]. The investigated C. elegans telomeric sequence is shown to fold into an intramolecular two G-tetrads basket type G-quadruplex structure that includes a C-T base pair in the diagonal loop. This work sheds light on the telomeric structure of the widely used C. elegans animal model.
G-quadruplex structure of the C. elegans telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C-T base-pair.,Marquevielle J, De Rache A, Vialet B, Morvan E, Mergny JL, Amrane S Nucleic Acids Res. 2022 Jun 23. pii: 6613919. doi: 10.1093/nar/gkac523. PMID:35736226<ref>PMID:35736226</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7oqt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amrane, S]]
[[Category: Amrane S]]
[[Category: Marquevielle, J]]
[[Category: De Rache A]]
[[Category: Rache, A De]]
[[Category: Marquevielle J]]
[[Category: C. elegans telomere]]
[[Category: Dna]]
[[Category: G-quadruplex]]
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