Citric Acid Cycle

<StructureSection load='1cts' size='350' side='right' scene='User:Wayne_Decatur/1cts_to_2cts_(citrate_synthase)_morph_methods/Camorph/5' caption='Open conformation of citrate synthase dimer complex with citrate (PDB code 1cts) and closed conformation of citrate synthase dimer complex with citrate and CoA (PDB code 2cts)'>

A Citric Acid Cycle Schematic

The Citric Acid Cycle is a key metabolic pathway that connects carbohydrate, fat, and protein metabolism.

The Citric Acid Cycle (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of glycolysis, along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH.

Step 0 / 10 - Aldol condensation - Citrate synthase

• Citrate Synthase

Articles in Proteopedia concerning Citric Acid Cycle include:

• Citrate Synthase Structure & Mechanism
• Aconitase
• Isocitrate Dehydrogenase
• 2-Oxoglutarate Dehydrogenase (also known as alpha-ketoglutarate dehydrogenase)
• Succinyl-CoA Synthetase
• Succinate Dehydrogenase
• Fumarase
• Malate Dehydrogenase
• Glutamate Dehydrogenase

To view Citric Acid Cycle related proteins which are Structure Index entries see:

• Aconitase

To view automatically seeded indices concerning Citric Acid Cycle See:

• Citric Acid Cycle

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, David Canner, Ann Taylor, Wayne Decatur, Jaime Prilusky