Citric Acid Cycle: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH. | The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH. | ||
[[Pyruvate dehydrogenase]] | [[Pyruvate dehydrogenase]] | ||
The multienzyme complex together catalyzes five distinct reactions in the conversion of pyruvate to acetyl-CoA. The overall result is described by the following reaction: | |||
Pyruvate + CoA + NAD+ ==> Acetyl-CoA + CO2 + NADH | |||
However, pyruvate dehydrogenase (E1) is responsible for only the first two of the five reactions. The first of these is the decarboxylation of pyruvate and coupling of thiamine pyrophosphate (TPP) to form hydroxyethyl-TPP. | |||
Pyruvate + TPP ==> Hydroxyethyl-TPP + CO2 | |||
'''Step 0 / 10 - Aldol condensation - Citrate synthase''' | '''Step 0 / 10 - Aldol condensation - Citrate synthase''' | ||
