7f90: Difference between revisions

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'''Unreleased structure'''


The entry 7f90 is ON HOLD  until 2023-10-06
==Crystal structure of SARS auxiliary protein in complex with human nuclear protein==
 
<StructureSection load='7f90' size='340' side='right'caption='[[7f90]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
Authors: Gao, X., Cui, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7f90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F90 FirstGlance]. <br>
Description: Crystal structure of SARS auxiliary protein in complex with human nuclear protein
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f90 OCA], [https://pdbe.org/7f90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f90 RCSB], [https://www.ebi.ac.uk/pdbsum/7f90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f90 ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Gao, X]]
== Function ==
[[Category: Cui, S]]
[[https://www.uniprot.org/uniprot/NS6_SARS NS6_SARS]] Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex (PubMed:33849972). Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:17596301). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (PubMed:17596301). Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:17596301).<ref>PMID:17596301</ref> <ref>PMID:33849972</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Severe acute respiratory syndrome-related coronavirus]]
[[Category: Cui S]]
[[Category: Gao X]]
Retrieved from "https://proteopedia.org/7f90"