7d8b: Difference between revisions
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==== | ==Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways== | ||
<StructureSection load='7d8b' size='340' side='right'caption='[[7d8b]]' scene=''> | <StructureSection load='7d8b' size='340' side='right'caption='[[7d8b]], [[Resolution|resolution]] 2.46Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7d8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8B FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8b OCA], [https://pdbe.org/7d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8b RCSB], [https://www.ebi.ac.uk/pdbsum/7d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8b ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8b OCA], [https://pdbe.org/7d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8b RCSB], [https://www.ebi.ac.uk/pdbsum/7d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8b ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Brown CJ]] | ||
[[Category: Frosi Y]] | |||
[[Category: Jiang S]] | |||
[[Category: Lin YC]] | |||
