4csj: Difference between revisions

<table><tr><td colspan='2'>[[4csj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSJ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NN7:N-[(2S)-1-[[1-(4-FLUOROPHENYL)INDAZOL-4-YL]AMINO]PROPAN-2-YL]-2,4,6-TRIMETHYL-BENZENESULFONAMIDE'>NN7</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4csj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csj OCA], [https://pdbe.org/4csj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4csj RCSB], [https://www.ebi.ac.uk/pdbsum/4csj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4csj ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>  

[[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>  

*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]

[[Category: Homo sapiens]]

[[Category: Ahlgren R]]

[[Category: Backstrom S]]

[[Category: Bengtsson M]]

[[Category: Bladh H]]

[[Category: Dahmen J]]

[[Category: Edman K]]

[[Category: Hansson T]]

[[Category: Henriksson K]]

[[Category: Hillertz P]]

[[Category: Hulikal V]]

[[Category: Jerre A]]

[[Category: Kase C]]

[[Category: Kinchin L]]

[[Category: Lepisto M]]

[[Category: Mile I]]

[[Category: Nilsson S]]

[[Category: Smailagic A]]

[[Category: Taylor J]]

[[Category: Tjornebo A]]

[[Category: Wissler L]]